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16.01.2018

New IL-6R Inhibitory Antibodies, Approved by FDA, Release Now!

Inhibitor Expert (Inhibitors, Modulators, Libraries)
Signaling Pathway Screening Library Catalog New Inhibitor
New IL-6R Inhibitory Antibodies
FDA-approved Antibodies for Rheumatoid Arthritis  
   
Tocilizumab 
LY294002
Synonyms: MRA
Tocilizumab is a humanized monoclonal antibody that binds to the IL-6R, MW: 148 KD.
The FDA approved tocilizumab to treat moderate to severely active rheumatoid arthritis,systemic juvenile idiopathic arthritis and polyarticular juvenile idiopathic arthritis.
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Sarilumab 
Nutlin-3-chemical-structure
Synonyms: SAR153191, REGN88
Sarilumab is a fully humanized IL-6R mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.
FDA approval of sarilumab for the treatment of moderate to severely active rheumatoid arthritis in adult patients.
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Adalimumab 
Synonyms: LU200134, D2E7
Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.
Adalimumab receives FDA Approval for First-Line Treatment of Moderate to Severe Rheumatoid Arthritis
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